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KMID : 0381219880200030323
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Journal of RIMSK
1988 Volume.20 No. 3 p.323 ~ p.330
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A Clinical Effect of Sulbactam/Ampicillin for the Treatment of Surgical Infection
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Abstract
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Sulbactam (sodium penicillinate sulfone) is an irreversible inhibitor of many common bacterial beta-lactamases. The compound does not, by itself, possess useful antibacterial activity but, when combined with ampicillin, extends the antibacterial spectrum of the ampicillin to include most Bacteroides group organisms and is known to be effective for the infections caused by ampicillinresistant organisms.
So we evaluated the clinical efficacy and safety of ampicillin/sulbactam for the surgical infections and got the following results.
1) The total number of patients was 40, 28 male and 12 female.
2) There were 22 cases of appendical diseases, 10 cases of gastric and duodenal diseases, 5 cases of biliary tract diseases and 3 cases of miscellaneous diseases.
3) In the appendicitis group, 24 strains of organisms were cultured, of which E. coli was most common and 83.3% (of the organisms) were sensitive to Sulbactam/Ampicillin. The therapeutic efficacy was 95.5% in clinical cure rate and 58.3% in bacteriological cure rate.
4) Enterobacter, Pseudomonas and Klebsiella were common organisms to be cultured in the gastric and duodenal disease group. Most organisms (83.3%) were sensitive to Sulbactam/Ampicillin and the efficacy was 100% in clinical cure rate and 83.3% in bacteriological cure rate.
5) Enterobacter and E. coli were common organisms to be cultured in biliary tract disease group and most organisms (88.9%) were sensitive to Sulbactam/Ampicillin. The therapeutic efficacy was 80 in clinical cure and 77. 8% in bacteriological cure.
With the above results, we could find the combination of Sulbactam/Ampicillin to be safe and effective in the treatment of surgical infections.
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